Hspd1 Mouse shRNA Plasmid (Locus ID 15510)

SKU
TG501012
Hspd1 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
$883.00
In Stock*
Specifications
Product Data
Locus ID 15510
Synonyms 60kDa; CPN60; HSP-60; HSP-65; Hsp60
Vector pGFP-V-RS
E. coli Selection Kan
Format Retroviral plasmids
Components Hspd1 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 15510). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq BC016400, NM_010477, NM_001356512, NM_010477.1, NM_010477.2, NM_010477.3, NM_010477.4, BC018545, BC106112
UniProt ID P63038
Summary Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein.[UniProtKB/Swiss-Prot Function]
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
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