BMAL1 (ARNTL) Human shRNA Plasmid Kit (Locus ID 406)

SKU TG314656

ARNTL - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided

Product Data

• Locus ID: 406
• Synonyms: bHLHe5; BMAL1; BMAL1c; JAP3; MOP3; PASD3; TIC
• Vector: pGFP-V-RS
• E. coli Selection: Kan
• Format: Retroviral plasmids
• Components: ARNTL - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 406). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
• RefSeq: NM_001030272, NM_001030273, NM_001178, NM_001297719, NM_001297722, NM_001297724, NM_001351804, NM_001351805, NM_001351806, NM_001351807, NM_001351808, NM_001351809, NM_001351810, NM_001351811, NM_001351812, NM_001351813, NM_001351814, NM_001351815, NM_001351816, NM_001351817, NM_001351818, NM_001351819, NM_001351820, NM_001351821, NM_001351822, NM_001351823, NM_001351824, NR_147785, NR_147786, NR_147787, NR_147788, NR_147789, NR_147790, NR_147791, NM_001030273.1, NM_001030273.2, NM_001178.1, NM_001178.2, NM_001178.3, NM_001178.4, NM_001178.5, NM_001030272.1, NM_001030272.2, NM_001297724.1, NM_001297719.1, NM_001297722.1, BC016674, BC016674.1, BC041129, BC041129.1, BC031214, NM_001297719.2
• UniProt ID: O00327
• Summary: The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient