RASSF1 Human shRNA Plasmid Kit (Locus ID 11186)

SKU TG307696

RASSF1 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided

Product Data

• Locus ID: 11186
• Synonyms: 123F2; NORE2A; RASSF1A; RDA32; REH3P21
• Vector: pGFP-V-RS
• E. coli Selection: Kan
• Format: Retroviral plasmids
• Components: RASSF1 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 11186). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
• RefSeq: NM_001206957, NM_007182, NM_170712, NM_170713, NM_170714, NM_170715, NM_170716, NM_170717, NM_170712.1, NM_170712.2, NM_170713.1, NM_170713.2, NM_007182.1, NM_007182.2, NM_007182.3, NM_007182.4, NM_170714.1, NM_001206957.1, NM_170715.1, NM_170716.1, NM_170717.1, BC110412, BC110412.1, BC117153, BC143879, BM152368, BM562405, NM_170713.3, NM_170714.2, NM_170712.3, NM_007182.5
• UniProt ID: Q9NS23
• Summary: This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, May 2011]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient