BAX Human shRNA Plasmid Kit (Locus ID 581)

SKU TF306440

BAX - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector, 5µg of each construct provided

Product Data

• Locus ID: 581
• Synonyms: BCL2L4
• Vector: pRFP-C-RS
• E. coli Selection: Chloramphenicol (34 ug/ml)
• Format: Retroviral plasmids
• Components: BAX - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector(Gene ID = 581). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pRFP-C-RS Vector, TR30015, included for free.
• RefSeq: NM_001291428, NM_001291429, NM_001291430, NM_001291431, NM_004324, NM_138761, NM_138762, NM_138763, NM_138764, NM_138765, NR_027882, NM_138761.1, NM_138761.3, NM_138764.1, NM_138764.2, NM_138764.3, NM_138764.4, NM_004324.1, NM_004324.2, NM_004324.3, NM_138763.1, NM_138763.2, NM_138763.3, NM_001291431.1, NM_001291430.1, NM_001291429.1, NM_001291428.1, NM_138765.2, BC014175, BC014175.2, BM673184, BM706954, NM_001291429.2, NM_138761.4, NM_004324.4, NM_001291431.2, NM_138764.5, NM_138763.4, NM_001291428.2
• UniProt ID: Q07812
• Summary: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. The association and the ratio of BAX to BCL2 also determines survival or death of a cell following an apoptotic stimulus. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Dec 2019]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient