Wilms Tumor Protein (WT1) (NM_024424) Human Recombinant Protein

CAT#: TP762366

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Purified recombinant protein of Human Wilms tumor 1 (WT1), transcript variant B, Met1-Ala78-GGGGS-Lys141-Gly229, with N-terminal His tag, expressed in E.coli, 50ug

USD 226.00

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    • 50 ug

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Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
A DNA sequence encoding the region(Met1-Ala78-GGGGS-Lys141-Gly229) of WT1
Tag N-His
Predicted MW 17.9 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25mM Tris, pH8.0, 150mM NaCl, 10% glycerol
Storage Store at -80°C after receiving vials.
Stability Stable for at least 1 year from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_077742
Locus ID 7490
UniProt ID P19544, Q6PI38
Cytogenetics 11p13
Refseq Size 3020
Refseq ORF 1542
Synonyms AWT1; GUD; NPHS4; WAGR; WIT-2; WT33
Summary This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015]
Protein Families Druggable Genome, Transcription Factors


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