CLACP (COL25A1) (NM_198721) Human Recombinant Protein

SKU TP762281

Purified recombinant protein of Human collagen, type XXV, alpha 1 (COL25A1), transcript variant 1, Lys573-Gln653, with N-terminal His-ABP tag, expressed in E.coli, 50ug

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  A DNA sequence encoding the region(Lys573-Gln653) of COL25A1
• Tag: N-His-ABP (Albumin-Binding Protein)
• Predicted MW: 23.5 kDa
• Concentration: >0.05 µg/µL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 50 mM Tris-HCl, pH 8.0, 8 M urea
• Note: For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
• Storage: Store at -80°C after receiving vials.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Shipping: Dry Ice

Reference Data

• RefSeq: NP_942014
• Locus ID: 84570
• UniProt ID: Q9BXS0
• Cytogenetics: 4q25
• RefSeq Size: 2607
• RefSeq ORF: 1962
• Synonyms: AMY; CFEOM5; CLAC; CLAC-P; CLACP
• Summary: This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
• Protein Families: Transmembrane