POLDIP1 (KCTD13) (NM_178863) Human Recombinant Protein

SKU TP761863

Purified recombinant protein of Human potassium channel tetramerisation domain containing 13 (KCTD13), full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  A DNA sequence encoding human full-length KCTD13
• Tag: N-GST and C-His
• Predicted MW: 64.2 kDa
• Concentration: >0.05 µg/µL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 50 mM Tris-HCl, pH 8.0, 8 M urea
• Note: For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
• Storage: Store at -80°C.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Shipping: Dry Ice

Reference Data

• RefSeq: NP_849194
• Locus ID: 253980
• UniProt ID: Q8WZ19
• Cytogenetics: 16p11.2
• RefSeq Size: 1745
• RefSeq ORF: 987
• Synonyms: BACURD1; FKSG86; hBACURD1; PDIP1; POLDIP1
• Summary: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission (PubMed:19782033). The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome (PubMed:19782033) Degradation of RHOA regulates the actin cytoskeleton and promotes synaptic transmission (By similarity).[UniProtKB/Swiss-Prot Function]
• Protein Families: Ion Channels: Other, Transcription Factors