FGF2 (NM_002006) Human Recombinant Protein

CAT#: TP750002

Recombinant protein of human Fibroblast Growth Factor-basic (FGF2) produced in E. coli


 Product Datasheet for 'TP750002'

 Cited in 6 publications.

  View other "FGF2" proteins (10)

USD 411.00


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    • 100 ug


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Specifications

Product Data
Description Recombinant protein of human Fibroblast Growth Factor-basic (FGF2) produced in E. coli
Species Human
Expression Host E.Coli
Expression cDNA Clone or AA Sequence A DNA sequence encoding the region (Gly132-Ser288) of human FGF2
Tag Tag Free
Predicted MW 17.4 kDa
Concentration Resuspend the protein to the desired concentration in proper buffer.
Purity >95% as determined by SDS-PAGE and Coomassie blue staining
Buffer Lyophilized from a sterile solution containing 10 mM Tris.Cl, pH7.0, 150mM NaCl. Stable for at least 6 months from date of receipt under proper storage and handling conditions.
Bioactivity Measured in a cell proliferation assay using 3T3 cells. ED50 for this effect is typically 0.07-0.10 ng/ml.
Cell culture factor (PMID: 26253201)
Cell culture factor (PMID: 26704449)
Cell culture factor (PMID: 29416007)
Cell culture factor (PMID: 29937202)
Cell culture factor (PMID: 29948854)
Endotoxin <0.1 EU per 1 µg of the protein by the LAL
Reference Data
RefSeq NP_001997
Locus ID 2247
Refseq Size 6803
Cytogenetics 4q28.1
Refseq ORF 864
Synonyms BFGF; FGF-2; FGFB; HBGF-2
Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008]
Protein Families Secreted Protein, Druggable Genome
Protein Pathways MAPK signaling pathway, Regulation of actin cytoskeleton, Pathways in cancer, Melanoma

Citations (6)

Documents

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