Gzmb Mouse Recombinant Protein

SKU TP726880

Recombinant Mouse Granzyme B (G,H)/GZMB (C-6His)

Product Data

• Species: Mouse
• Protein Source: Human
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Gly19-Ser247
• Tag: C-His
• Buffer: Supplied as a 0.2 um filtered solution of PBS, pH 7.4.
• Note: Recombinant Mouse Granzyme B is produced by our Mammalian expression system and the target gene encoding Gly19-Ser247 is expressed with a 6His tag at the C-terminus.
• Storage: Store at < -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
• Stability: 12 months from date of despatch
• Shipping: Dry Ice

Reference Data

• Locus ID: 14939
• UniProt ID: P04187
• Synonyms: Granzyme B(G;H);CTLA-1;Cytotoxic cell protease 1;CCP1;Fragmentin-2;Gzmb;Ctla-1; Ctla1
• Summary: Granzyme B(GZMB) contains 1 peptidase S1 domain and belongs to the peptidase S1 family. This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp and seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. The protein cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.