beta 2 Microglobulin (B2M) Human Recombinant Protein

SKU TP726739

Recombinant Human HLA-A*0201 NY-ESO-1 complex Protein (C-10His)

Product Data

• Species: Human
• Protein Source: Human
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Ile21-Met119&Gly25-Ile308 (Ala269Val)
• Tag: C-10His
• Buffer: Lyophilized from a 0.2 um filtered solution of 20mM PB, 500mM NaCl, pH7.4.
• Note: Recombinant Human B2M&HLA-A is produced by our Mammalian expression system and the target gene encoding Ile21-Met119&Gly25-Ile308 (Ala269Val) is expressed with a 10His tag at the C-terminus.
• Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
• Stability: 12 months from date of despatch
• Shipping: Ambient

Reference Data

• Locus ID: 567
• UniProt ID: P61769
• Synonyms: MHC; MY-ESO-1
• Summary: NY-ESO-1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy. Optimally assembled peptide-HLA-B2M trimer translocates to the surface of antigen-presenting cells, where it interacts with TCR and CD8 coreceptor on the surface of T cells.
• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Antigen processing and presentation