Il6ra Mouse Recombinant Protein

SKU TP726683

Recombinant Mouse IL-6RA (C-6His)

Product Data

• Species: Mouse
• Protein Source: Human
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Leu20-Pro364
• Tag: C-6His
• Buffer: Lyophilized from a 0.2 um filtered solution of PBS,pH7.4.
• Note: Recombinant Mouse Interleukin-6 receptor subunit alpha is produced by our Mammalian expression system and the target gene encoding Leu20-Pro364 is expressed with a 6His tag at the C-terminus.
• Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
• Stability: 12 months from date of despatch
• Shipping: Ambient

Reference Data

• Locus ID: 16194
• UniProt ID: P22272
• Synonyms: Interleukin-6 receptor subunit alpha;IL-6R subunit alpha;IL-6R-alpha;IL-6R 1;Membrane glycoprotein 80;gp80;CD126
• Summary: Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. IL6Ra is a part of the receptor for interleukin 6 cytokine. IL6Ra binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitates an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer.