Enkephalin (PENK) Human Recombinant Protein

SKU TP726149

Recombinant Human Proenkephalin-A (C-6His)

Product Data

• Species: Human
• Protein Source: Human
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Glu25-Phe267
• Tag: C-His
• Buffer: Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl,pH7.4, 5% trehalose, 0.05%Tween80
• Note: Recombinant Human Proenkephalin-A is produced by our Mammalian expression system and the target gene encoding Glu25-Phe267 is expressed with a 6His tag at the C-terminus.
• Stability: 12 months from date of despatch
• Shipping: Ambient

Reference Data

• Locus ID: 5179
• UniProt ID: P01210
• Synonyms: Proenkephalin-A; Synenkephalin; Met-Enkephalin; Leu-Enkephalin; PENK
• Summary: Proenkephalin-A is a secreted protein that belongs to the opioid neuropeptide precursor family. Proenkephalin-A is an endogenous opioid polypeptide hormone which, via proteolyic cleavage, produces the enkephalin peptides [Met]enkephalin, and to a lesser extent, [Leu]enkephalin. Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. Proenkephalin-A (114-133) and Proenkephalin-A (237-258) increase glutamate release in the striatum. Proenkephalin-A (114-133) decreases GABA concentration in the striatum.
• Protein Families: Secreted Protein