Apoe Mouse Recombinant Protein

SKU TP724887

Recombinant Mouse Apolipoprotein E/ApoE (C-His)

Product Data

• Species: Mouse
• Protein Source: Human 293
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Glu19-Gln311
• Tag: C-6His
• Buffer: Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, 0.1%Tween 80, 10% trehalose, pH 7.4
• Note: Recombinant Mouse Apolipoprotein E is produced by our Mammalian expression system and the target gene encoding Glu19-Gln311 is expressed with a 6His tag at the C-terminus.
• Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
• Stability: 12 months from date of despatch
• Shipping: Ambient

Reference Data

• Locus ID: 11816
• UniProt ID: P08226
• Synonyms: Apolipoprotein E; Apo-E;APOE
• Summary: Apolipoprotein E (ApoE) is a glycoprotein that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. ApoE can be synthesized by the liver and intestinally synthesized chylomicrons. ApoE mediates high-affinity binding of chylomicrons and very low density lipoprotein (VLDL) particles to the LDL receptor, allowing for specific uptake of these particles by the liver, preventing the accumulation of cholesterol-rich particles in the plasma. ApoE plays an essential role in the formation of plasma lipoproteins and is involved in their production, conversion and clearance. ApoE is also a constituent of a subclass of high density of lipoproteins (HDL) involved in cholesterol transport. More recently, ApoE has been studied for its role in several biological processes not directly related to lipoprotein transport, including Alzheimer's disease, immunoregulation, and cognition.