CD16 (FCGR3A) Human Recombinant Protein

SKU TP723977

Human FCGR3A Protein, His Tag

Product Data

• Species: Human
• Expression Host: HEK293
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  FCGR3A（Gly17-Gly206）(F176V)+6×His tag
• Tag: C-6×His
• Predicted MW: 22.3 kDa
• Purity: > 95%
• Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5% - 8% trehalose is added as protectants before lyophilization
• Reconstitution Method: Reconstitute with deionized water
• Preparation: Affinity purification
• Storage: Store the lyophilized protein at -20°C.; After reconstitution, store the protein at -80°C for 12 months.; Avoid repeated freezing and thawing.
• Stability: 12 months from date of despatch
• Shipping: Ambient

Reference Data

• Locus ID: 2214
• UniProt ID: P08637
• Summary: This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Protein Families: ES Cell Differentiation/IPS, Secreted Protein, Transmembrane
• Protein Pathways: Fc gamma R-mediated phagocytosis, Natural killer cell mediated cytotoxicity, Systemic lupus erythematosus