TNFRSF1A (NM_001065) Human Recombinant Protein

CAT#: TP723870

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Purified recombinant protein of Human tumor necrosis factor receptor superfamily, member 1A (sTNF-RI / TNFRSF1A)


 Product Datasheet for 'TP723870'

  View other "TNFRSF1A" proteins (11)

USD 195.00


Availability*
5 Days

Size
    • 10 ug


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Specifications

Product Data
Description Purified recombinant protein of Human tumor necrosis factor receptor superfamily, member 1A (sTNF-RI / TNFRSF1A)
Species Human
Expression Host E. coli
Tag Tag Free
Predicted MW 21.4 kDa
Concentration Protein formulated and vialed at >50 ug/mL in specified buffer
Purity >95%, as determined by Coomassie stained SDS-PAGE.
Buffer 1 x PBS
Bioactivity The ED50 is 0.045-0.01 µg/ml, corresponding to a specific activity of 1.0-2.2 x 104 units/mg, determined by a dose-dependent inhibition of 0.25 ng/ml TNF-a induced cytotoxicity in L929 mouse fibroblast cells in the presence of 4 µg/ml actinomycin D.
Endotoxin Less than 0.01 ng per µg protein as determined by the LAL method
Reference Data
RefSeq NP_001056
Locus ID 7132
Refseq Size 2236
Cytogenetics 12p13.31
Refseq ORF 1365
Synonyms CD120a; FPF; MS5; p55; p55-R; p60; TBP1; TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55
Summary This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients. [provided by RefSeq, Sep 2016]
Protein Families Druggable Genome, Secreted Protein, Transcription Factors, Transmembrane
Protein Pathways Adipocytokine signaling pathway, Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Cytokine-cytokine receptor interaction, MAPK signaling pathway

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USD 360.00

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