Il17a (NM_010552) Mouse Recombinant Protein

SKU TP723750

Purified recombinant protein of Mouse interleukin 17A (Il17a)

Product Data

• Species: Mouse
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Mouse IL-17A, the region of Ala26-Ala158, from gene Accession# NM_010552
• Tag: Tag Free
• Predicted MW: 15 kDa
• Concentration: lot specific
• Purity: Purity is >98%, as determined by Coomassie stained SDS-PAGE.
• Buffer: 10 mM NaH2PO4, 0.15 M NaCl, pH 7.2
• Bioactivity: The ED50 is 0.25 - 1 ng/ml, corresponding to a specific activity 1.0 - 4 x 10^6 units/mg, determined by a dose dependent stimulation of fetal mouse skin fibroblasts production of IL-6.
• Endotoxin: Less than 0.01 ng per ug protein as determined by the LAL method
• Storage: Store at -80°C.
• Stability: Unopened vial can be stored between 2°C and 8°C for up to 2 weeks, at -20°C for up to 6 months, or at -70°C or below until the expiration date. Aliquots can be stored between 2°C and 8°C for up to one week and stored at -20°C or colder for up to 3 months. Avoid repeated freeze/thaw cycles.
• Shipping: Dry Ice

Reference Data

• RefSeq: NP_034682
• Locus ID: 16171
• UniProt ID: Q62386
• Cytogenetics: 1 A4
• RefSeq Size: 1171
• RefSeq ORF: 474
• Synonyms: Ctl; Ctla; Ctla-8; Ctla8; Il; IL-; IL-17; IL-17A; Il17
• Summary: This gene encodes a pro-inflammatory cytokine that is a member of the interleukin-17 family. The encoded protein plays a central role in host defense against diverse pathogens. The encoded protein is produced by activated T-cells and certain cell types of innate immune system. The active protein functions as either a homodimer with other interleukin-17 family members and signals through the interleukin-17 receptor to induce inflammatory cytokine production. Aberrant expression of this gene is associated with autoinflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Sep 2015]