IL23 (IL23A) (NM_016584) Human Recombinant Protein

CAT#: TP723221

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Purified recombinant protein of Human interleukin 23, alpha subunit p19 (IL23A).


 Product Datasheet for 'TP723221'

 Cited in 1 publication.

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USD 230.00


Availability*
2 Weeks

Size
    • 10 ug


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Specifications

Product Data
Description Purified recombinant protein of Human interleukin 23, alpha subunit p19 (IL23A).
Species Human
Expression Host Hi-5 insect
Tag Tag Free
Predicted MW 53.5 kDa
Concentration Resuspend the protein in the desired concentration in proper buffer
Purity >95% as determined by SDS-PAGE and Coomassie blue staining
Buffer Lyophilized from a 0.2 µM filtered solution of 20mM phosphate buffer,100mM NaCl, pH 7.2
Bioactivity Measured by its ability to induce IL-17 secretion by mouse splenocytes.
Co-immunoprecipitation (PMID: 27019190)
Endotoxin Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg)
Reference Data
RefSeq NP_057668
Locus ID 51561
Refseq Size 1049
Cytogenetics 12q13.3
Refseq ORF 567
Synonyms IL-23; IL-23A; IL23P19; P19; SGRF
Summary This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

Citations (1)

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68 Mouse Clones
HUMAN PROREINS 101