MAN1B1 (NM_016219) Human Recombinant Protein

SKU TP720726L

Purified recombinant protein of Human mannosidase, alpha, class 1B, member 1 (MAN1B1)

Product Data

• Species: Human
• Expression Host: HEK293
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Asp106-Ala699
• Tag: C-His
• Predicted MW: 68.7 kDa
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: Supplied as a 0.2 um filtered solution of 50mM TrisHCL, 10mM reduced Glutathione, pH 8.0.
• Endotoxin: Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg)
• Storage: Store at < -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
• Stability: Stable for at least 3 months from date of receipt under proper storage and handling conditions.
• Shipping: Dry Ice

Reference Data

• RefSeq: NP_057303
• Locus ID: 11253
• UniProt ID: Q9UKM7
• Cytogenetics: 9q34.3
• RefSeq Size: 2787
• RefSeq ORF: 2097
• Synonyms: ERMAN1; ERManI; MANA-ER; MRT15
• Summary: This gene encodes an enzyme belonging to the glycosyl hydrolase 47 family. This enzyme functions in N-glycan biosynthesis, and is a class I alpha-1,2-mannosidase that specifically converts Man9GlcNAc to Man8GlcNAc isomer B. It is required for N-glycan trimming to Man5-6GlcNAc2 in the endoplasmic-reticulum-associated degradation pathway. Mutations in this gene cause autosomal-recessive intellectual disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Dec 2011]
• Protein Families: Transmembrane
• Protein Pathways: Metabolic pathways, N-Glycan biosynthesis