Thimet Oligopeptidase (THOP1) (NM_003249) Human Recombinant Protein

SKU TP720157

Recombinant protein of human thimet oligopeptidase 1 (THOP1)

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Lys2-Cys689
• Tag: C-His
• Predicted MW: 79.9 kDa
• Concentration: lot specific
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: Supplied as a 0.2 um filtered solution of 20mM PB, 100mM NaCl, 10% Glycerol, pH 7.0.
• Endotoxin: < 0.1 EU per µg protein as determined by LAL test
• Storage: Store at < -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
• Stability: Stable for at least 3 months from date of receipt under proper storage and handling conditions.
• Shipping: Dry Ice

Reference Data

• RefSeq: NP_003240
• Locus ID: 7064
• UniProt ID: P52888
• Cytogenetics: 19p13.3
• Synonyms: EP24.15; MEPD_HUMAN; MP78; TOP
• Summary: The protein encoded by this gene is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. This protein also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides. [provided by RefSeq, Nov 2015]
• Protein Families: Druggable Genome, Protease
• Protein Pathways: Renin-angiotensin system