Cortactin (CTTN) (NM_138565) Human Recombinant Protein
SKU
TP710315
Purified recombinant protein of Human cortactin (CTTN / EMS1), transcript variant 2, full length, with C-terminal DDK tag, expressed in sf9, 20ug
$540.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | Sf9 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-DDK |
| Predicted MW | 57.3 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 50 mM Tris-HCl, 100 mM glycine, pH 8.0, 10% glycerol |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_612632 |
| Locus ID | 2017 |
| UniProt ID | Q14247 |
| Cytogenetics | 11q13.3 |
| RefSeq Size | 3208 |
| RefSeq ORF | 1539 |
| Synonyms | EMS1 |
| Summary | This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. provided by RefSeq, May 2010 |
| Protein Categories | Intracellular Proteins |
| Protein Families | Druggable Genome |
| Protein Pathways | Pathogenic Escherichia coli infection, Tight junction |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "Cortactin" proteins (8)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH301111 | CTTN MS Standard C13 and N15-labeled recombinant protein (NP_612632) | 10 ug |
$3,360.00
|
|
| LC403359 | Lyophilized CTTN HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC417430 | Lyophilized CTTN HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC429248 | Lyophilized CTTN HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY403359 | Transient overexpression lysate of cortactin (CTTN), transcript variant 2 (as WB positive control) | 100 ug |
$436.00
|
|
| LY417430 | Transient overexpression lysate of cortactin (CTTN), transcript variant 1 (as WB positive control) | 100 ug |
$665.00
|
|
| LY429248 | Transient overexpression lysate of cortactin (CTTN), transcript variant 1 (as WB positive control) | 100 ug |
$436.00
|
|
| TP301111 | Recombinant protein of human cortactin (CTTN), transcript variant 2, 20 µg | 20 ug |
$867.00
|
|
Citations
Anti-Cortactin Autoantibodies Are Associated With Key Clinical Features in Adult Myositis But Are Rarely Present in Juvenile Myositis
Pinal-Fernandez, Pak, Gil-Vila et al
Arthritis Rheumatol (2022) 74 (2), 358-364 DOI: 10.1002/art.41931
Pinal-Fernandez, Pak, Gil-Vila et al
Arthritis Rheumatol (2022) 74 (2), 358-364 DOI: 10.1002/art.41931
Cited by 8
AI Summary: OriGene products contributed to this study by providing the recombinant human cortactin protein (OriGene, TP305482) used as the antigen in the enzyme-linked immunosorbent assay (ELISA) to detect anti-cortactin autoantibodies in patient samples.
Diagnostic utility of cortactin antibodies in myasthenia gravis
Illa, Cortés-Vicente, Martínez et al
Ann. N. Y. Acad. Sci. (2017)
Illa, Cortés-Vicente, Martínez et al
Ann. N. Y. Acad. Sci. (2017)
Cited by 47
AI Summary: OriGene’s purified recombinant cortactin protein was used to coat ELISA plates, enabling the detection of anti-cortactin antibodies in patient sera and supporting the identification of cortactin as a novel biomarker in myasthenia gravis.
Snippet: Hospital de la Santa Creu i Sant Pau. For the study of anti-cortactin antibodies, we designed an in-house enzyme-linked immunosorbent assay (ELISA) with plates containing purified recombinant cortactin (OriGene, Rockville, MD)
Inhibitory cortactin nanobodies delineate the role of NTA- and SH3-domain-specific functions during invadopodium formation and cancer cell invasion
Bertier, Boucherie, Zwaenepoel et al
FASEB J. (2017)
Bertier, Boucherie, Zwaenepoel et al
FASEB J. (2017)
AI Summary: OriGene contributed to this study by providing cortactin cDNA, which was used for cloning and recombinant protein production to investigate the role of cortactin domains in invadopodium formation and cancer cell invasion.
Snippet: A VHH library of independent transformants was obtained, subjected to five con- secutive rounds of panning, and further analyzed by ELISA and sequence analysis. Cloning and recombinant protein production Cortactin cDNA was obtained from Origene (Rockville, ... All 3 versions Cite SaveSaving
Clinical Characteristics of Patients With Double-Seronegative Myasthenia Gravis and Antibodies to Cortactin
Cortés-Vicente, Gallardo, Martínez et al
JAMA Neurol (2016)
Cortés-Vicente, Gallardo, Martínez et al
JAMA Neurol (2016)
Cited by 112
AI Summary: In this study, OriGene’s purified recombinant cortactin protein was used in Western blot assays to confirm the presence of cortactin antibodies in patient samples, enabling identification of a subgroup of double-seronegative myasthenia gravis patients with these antibodies.
Snippet: Cortac- tin antibodies were measured using the in-house enzyme- linked immunosorbent assay, and the results were confirmed by Western blot using a purified recombinant protein cortac- tin (OriGene) as previously described.19 A positive control and a ... Cited by 1 Cite SaveSaving
Cortactin autoantibodies in myasthenia gravis
Gallardo, Martínez-Hernández, Titulaer et al
Autoimmun Rev (2014)
Gallardo, Martínez-Hernández, Titulaer et al
Autoimmun Rev (2014)
Cited by 112
AI Summary: OriGene’s purified recombinant cortactin protein was used to coat ELISA plates, enabling the detection of cortactin autoantibodies in patient sera for this study on myasthenia gravis.
Snippet: Briefly, 96-well ELISA plates (NUNC, Kamstrup,Denmark) were coated with 100 ng/well of purified recombinant cortactin (OriGene, Rockville, Maryland,USA) diluted in phosphate-buffered saline (PBS) and left to stand overnight at 4 °C. Wells were incubated for ... Cited by 1 Cite SaveSaving
Showing 1-5 of 5 papers.
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