Cortactin (CTTN) (NM_138565) Human Recombinant Protein

CAT#: TP710315

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Purified recombinant protein of Human cortactin (CTTN / EMS1), transcript variant 2, full length, with C-terminal DDK tag, expressed in sf9, 20ug


 Product Datasheet for 'TP710315'

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USD 425.00


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    • 20 ug


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Specifications

Product Data
Description Purified recombinant protein of Human cortactin (CTTN / EMS1), transcript variant 2, full length, with C-terminal DDK tag, expressed in sf9, 20ug
Species Human
Expression Host Sf9
Tag C-DDK
Predicted MW 57.3 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol.
Reference Data
RefSeq NP_612632
Locus ID 2017
Refseq Size 3208
Cytogenetics 11q13.3
Refseq ORF 1539
Synonyms EMS1
Summary This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]
Protein Families Druggable Genome
Protein Pathways Pathogenic Escherichia coli infection, Tight junction

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