DCAMKL1 (DCLK1) (NM_001195416) Human Recombinant Protein

CAT#: TP331229

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Purified recombinant protein of Homo sapiens doublecortin-like kinase 1 (DCLK1), transcript variant 3.


 Product Datasheet for 'TP331229'

 Cited in 1 publication.

  View other "DCLK1" proteins (5)

USD 748.00


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    • 20 ug


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Specifications

Product Data
Description Purified recombinant protein of Homo sapiens doublecortin-like kinase 1 (DCLK1), transcript variant 3.
Species Human
Expression Host HEK293T
Tag C-Myc/DDK
Predicted MW 48.1
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Bioactivity ELISA standard (PMID: 29577277)
Preparation NULL or Add: Recombinant proteins was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_001182345
Locus ID 9201
Cytogenetics 13q13.3
Refseq ORF 1299
Synonyms CL1; CLICK1; DCAMKL1; DCDC3A; DCLK
Summary This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities. [provided by RefSeq, Sep 2010]
Protein Families Druggable Genome, Protein Kinase

Citations (1)

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