Glucokinase (GCK) (NM_033508) Human Recombinant Protein

CAT#: TP318920

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Recombinant protein of human glucokinase (hexokinase 4) (GCK), transcript variant 3


 Product Datasheet for 'TP318920'

  View other "GCK" proteins (15)

USD 748.00


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Size
    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human glucokinase (hexokinase 4) (GCK), transcript variant 3
Species Human
Expression Host HEK293T
Tag C-Myc/DDK
Predicted MW 51.9 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_277043
Locus ID 2645
Refseq Size 2566
Cytogenetics 7p13
Refseq ORF 1392
Synonyms FGQTL3; GK; GLK; HHF3; HK4; HKIV; HXKP; LGLK; MODY2
Summary This gene encodes a member of the hexokinase family of proteins. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. The use of multiple promoters and alternative splicing of this gene result in distinct protein isoforms that exhibit tissue-specific expression in the pancreas and liver. In the pancreas, this enzyme plays a role in glucose-stimulated insulin secretion, while in the liver, this enzyme is important in glucose uptake and conversion to glycogen. Mutations in this gene that alter enzyme activity have been associated with multiple types of diabetes and hyperinsulinemic hypoglycemia. [provided by RefSeq, Aug 2017]
Protein Families Druggable Genome
Protein Pathways Amino sugar and nucleotide sugar metabolism, Galactose metabolism, Glycolysis / Gluconeogenesis, Insulin signaling pathway, Maturity onset diabetes of the young, Metabolic pathways, Starch and sucrose metabolism, Type II diabetes mellitus

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Other Versions

Frequently bought together (2)
Clone OTI4C5, Anti-DDK (FLAG) monoclonal antibody
    • 100 ul

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GCK mouse monoclonal antibody, clone OTI3E3 (formerly 3E3)
    • 100 ul

USD 379.00

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68 Mouse Clones
HUMAN PROREINS 101