IRE1(ERN1) (NM_001433) Human Recombinant Protein

CAT#: TP315023

Recombinant protein of human endoplasmic reticulum to nucleus signaling 1 (ERN1)


 Product Datasheet for 'TP315023'

 Cited in 2 publications.

  View other "ERN1" proteins (3)

USD 788.00


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Size
    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human endoplasmic reticulum to nucleus signaling 1 (ERN1)
Species Human
Expression Host HEK293T
Expression cDNA Clone or AA Sequence Recombinant protein was produced with TrueORF clone, RC215023. Click on the TrueORF clone link to view cDNA and protein sequences.
Tag C-MYC/DDK
Predicted MW 109.6 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. Store at –80C. Avoid repeated freeze-thaw cycles. Stable for 3 months from receipt of products under proper storage and handling conditions.
Bioactivity WB positive control (PMID: 27622292)
Binding assay (ITC) (PMID: 28416388)
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_001424
Locus ID 2081
Refseq Size 3620
Cytogenetics 17q23.3
Refseq ORF 2931
Synonyms hIRE1p; IRE1; IRE1a; IRE1P
Summary This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1. [provided by RefSeq, Aug 2017]
Protein Families Protein Kinase, Transmembrane
Protein Pathways Alzheimer's disease

Citations (2)

Documents

Other Versions

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