IL23 (IL23A) (NM_016584) Human Recombinant Protein
Recombinant protein of human interleukin 23, alpha subunit p19 (IL23A)
Specifications
Product Data | |
Description | Recombinant protein of human interleukin 23, alpha subunit p19 (IL23A) |
Species | Human |
Expression Host | HEK293T |
Expression cDNA Clone or AA Sequence | Recombinant protein was produced with TrueORF clone, RC209680. Click on the TrueORF clone link to view cDNA and protein sequences. |
Tag | C-Myc/DDK |
Predicted MW | 18.6 kDa |
Concentration | >50 ug/mL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol |
Bioactivity | Protease substrate (PMID: 29038472) Cell treatment (PMID: 29038472) MS digestion (PMID: 29038472) |
Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Storage | Store at -80°C. |
Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Reference Data | |
RefSeq | NP_057668 |
Locus ID | 51561 |
Refseq Size | 1049 |
Cytogenetics | 12q13.3 |
Refseq ORF | 567 |
Synonyms | IL-23; IL-23A; IL23P19; P19; SGRF |
Summary | This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008] |
Protein Families | Druggable Genome, Secreted Protein |
Protein Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway |
Citations (2)
The use of this Proteins has been cited in the following citations: |
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Human neutrophils activated by TLR8 agonists, with or without IFNγ, synthesize and release EBI3, but not IL-12, IL-27, IL-35, or IL-39
,Cassatella, MA;Gardiman, E;Arruda-Silva, F;Bianchetto-Aguilera, F;Gasperini, S;Bugatti, M;Vermi, W;Larousserie, F;Devergne, O;Tamassia, N;,
J. Leukoc. Biol. 2020
,PubMed ID 32480433
[IL23A]
|
Phage-assisted continuous evolution of proteases with altered substrate specificity
,Packer, MS;Rees, HA;Liu, DR;,
Nat Commun 2017
,PubMed ID 29038472
[IL23A]
|
Documents
FAQs |
SDS |
Resources
Protein Resources |
Other Versions
SKU | Description | Size | Price |
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LC402570 | IL23A HEK293T cell transient overexpression lysate (as WB positive control) |
USD 110.00 |
|
LY402570 | Transient overexpression lysate of interleukin 23, alpha subunit p19 (IL23A) |
USD 360.00 |
|
PH309680 | IL23A MS Standard C13 and N15-labeled recombinant protein (NP_057668) |
USD 2,260.00 |
|
TP723221 | Purified recombinant protein of Human interleukin 23 (p19+p40). |
USD 240.00 |
|
TP723732 | Purified recombinant protein of Human interleukin 23 (p19+p40). |
USD 325.00 |
USD 350.00
USD 545.00