HLAG (HLA-G) (NM_002127) Human Recombinant Protein
Recombinant protein of human major histocompatibility complex, class I, G (HLA-G)
Specifications
Product Data | |
Description | Recombinant protein of human major histocompatibility complex, class I, G (HLA-G) |
Species | Human |
Expression Host | HEK293T |
Expression cDNA Clone or AA Sequence | Recombinant protein was produced with TrueORF clone, RC205216. Click on the TrueORF clone link to view cDNA and protein sequences. |
Tag | C-Myc/DDK |
Predicted MW | 38.3 kDa |
Concentration | >50 ug/mL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol |
Bioactivity | Cell treatment (PMID: 29985558) |
Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Storage | Store at -80°C. |
Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Reference Data | |
RefSeq | NP_002118 |
Locus ID | 3135 |
Refseq Size | 1578 |
Cytogenetics | 6p22.1 |
Refseq ORF | 1014 |
Synonyms | MHC-G |
Summary | HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008] |
Protein Families | Transmembrane |
Protein Pathways | Allograft rejection, Antigen processing and presentation, Autoimmune thyroid disease, Cell adhesion molecules (CAMs), Endocytosis, Graft-versus-host disease, Natural killer cell mediated cytotoxicity, Type I diabetes mellitus, Viral myocarditis |
Citations (4)
The use of this Proteins has been cited in the following citations: |
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Is there a role for HLA-G in the induction of regulatory T cells during the maintenance of a healthy pregnancy?
,Al-Khunaizi, NR;Tabbara, KS;Farid, EM;,
Am. J. Reprod. Immunol. 2020
,PubMed ID 32352606
[HLA-G]
|
Human Herpesvirus 6A and 6B inhibit in vitro angiogenesis by induction of Human Leukocyte Antigen G
,Rizzo, R;D'Accolti, M;Bortolotti, D;Caccuri, F;Caruso, A;Di Luca, D;Caselli, E;,
Sci Rep 2018
,PubMed ID 30523283
[HLA-G]
|
Effects of everolimus and HLA-G on cellular proliferation and neutrophil adhesion in an in vitro model of cardiac allograft vasculopathy
,Mociornita, AG;Adamson, MB;Tumiati, LC;Ross, HJ;Rao, V;Delgado, DH;,
Am. J. Transplant. 2018
,PubMed ID 29985558
[HLAG]
|
Soluble factors derived from human amniotic epithelial cells suppress collagen production in human hepatic stellate cells
,Hodge, A;Lourensz, D;Vaghjiani, V;Nguyen, H;Tchongue, J;Wang, B;Murthi, P;Sievert, W;Manuelpillai, U;,
Cytotherapy Mar 2014
,PubMed ID 24642017
[HLA-G1]
|
Documents
FAQs |
SDS |
Resources
Protein Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC419514 | HLA HEK293T cell transient overexpression lysate (as WB positive control) |
USD 110.00 |
|
LY419514 | Transient overexpression lysate of major histocompatibility complex, class I, G (HLA-G) |
USD 360.00 |
|
PH305216 | HLA MS Standard C13 and N15-labeled recombinant protein (NP_002118) |
USD 2,260.00 |
USD 350.00
USD 465.00