Fibrinogen gamma chain (27-437, His-tag) Human Protein

SKU AR51773PU-N

Fibrinogen gamma chain (27-437, His-tag) human recombinant protein, 0.1 mg

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  MGSSHHHHHH SSGLVPRGSH MGSYVATRDN CCILDERFGS YCPTTCGIAD FLSTYQTKVD KDLQSLEDIL HQVENKTSEV KQLIKAIQLT YNPDESSKPN MIDAATLKSR KMLEEIMKYE ASILTHDSSI RYLQEIYNSN NQKIVNLKEK VAQLEAQCQE PCKDTVQIHD ITGKDCQDIA NKGAKQSGLY FIKPLKANQQ FLVYCEIDGS GNGWTVFQKR LDGSVDFKKN WIQYKEGFGH LSPTGTTEFW LGNEKIHLIS TQSAIPYALR VELEDWNGRT STADYAMFKV GPEADKYRLT YAYFAGGDAG DAFDGFDFGD DPSDKFFTSH NGMQFSTWDN DNDKFEGNCA EQDGSGWWMN KCHAGHLNGV YYQGGTYSKA STPNGYDNGI IWATWKTRWY SMKKTTMKII PFNRLTIGEG QQHHLGGAKQ AGDV
• Tag: His-tag
• Predicted MW: 48.9 kDa
• Concentration: lot specific
• Purity: >90% by SDS - PAGE
• Presentation State: Purified
• Buffer: Presentation State: Purified; State: Liquid purified protein; Buffer System: Liquid, In Phosphate buffered saline (pH 7.4) containing 10% glycerol, 1 mM DTT
• Preparation: Liquid purified protein
• Protein Description: Recombinant human FGG, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
• Storage: Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice

Reference Data

• RefSeq: NP_000500
• Locus ID: 2266
• UniProt ID: P02679
• Cytogenetics: 4q32.1
• Synonyms: FGG, PRO2061, FIBG
• Summary: The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Complement and coagulation cascades