Mannan Binding (108-248, His-tag) Human Protein

SKU AR50636PU-N

Mannan Binding Protein (108-248, His-tag) human recombinant protein, 0.5 mg

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  MGSSHHHHHH SSGLVPRGSH MGSAASERKA LQTEMARIKK WLTFSLGKQV GNKFFLTNGE IMTFEKVKAL CVKFQASVAT PRNAAENGAI QNLIKEEAFL GITDEKTEGQ FVDLTGNRLT YTNWNEGEPN NAGSDEDCVL LLKNGQWNDV PCSTSHLAVC EFPI
• Tag: His-tag
• Predicted MW: 18 kDa
• Concentration: lot specific
• Purity: >90% by SDS - PAGE
• Presentation State: Purified
• Buffer: Presentation State: This purified protein is available in a denatured form, making it less suitable for functional studies. Denatured proteins are better suited for applications like Western Blot (WB) or imaging assays.; State: Liquid purified protein; Buffer System: 20 mM Tris-HCl buffer (pH 8.0) containing 2M Urea, 20% glycerol, 0.2M Nacl
• Preparation: Liquid purified protein
• Protein Description: Recombinant human MBL2 protein, fused to His-tag at N-terminus, was expressed in E.coli.
• Storage: Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice

Reference Data

• RefSeq: NP_000233
• Locus ID: 4153
• UniProt ID: P11226
• Cytogenetics: 10q21.1
• Synonyms: MBP, Mannose-binding protein C, MBP-C, MBP1, Mannan-binding protein, Mannose-binding lectin, MBL2, MBL
• Summary: This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes and binds to mannose and N-acetylglucosamine on many microorganisms, including bacteria, yeast, and viruses including influenza virus, HIV and SARS-CoV. This binding activates the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jun 2020]
• Protein Families: Druggable Genome
• Protein Pathways: Complement and coagulation cascades