CABIN1 Human Gene Knockout Kit (CRISPR)
CABIN1 - human gene knockout kit via CRISPRchange donor?
HDR-mediated knockout kit validation
KN211750G1, CABIN1 gRNA vector 1 in pCas-Guide vector
KN211750G2, CABIN1 gRNA vector 2 in pCas-Guide vector
donor DNA containing Left and right homologous arms and GFP-puro functional cassette.
GE100003, scramble sequence in pCas-Guide vector
|Disclaimer||The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.|
|RefSeq||NM_001199281, NM_001201429, NM_012295, XM_005261415, XM_005261416, XM_005261417, XM_005261419, XM_006724179, XM_006724180, XM_006724181, XM_011530026, XM_011530029, XM_011530030, XM_017028680, XM_017028681, XM_017028682, XM_017028683, XM_017028684, XR_001755184, XR_001755185|
|Synonyms||CAIN; KB-318B8.7; PPP3IN|
|Summary||Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms. [provided by RefSeq, Jan 2011].|
|Gene Expression Resources|