EXOSC6 Human Gene Knockout Kit (CRISPR)
EXOSC6 - human gene knockout kit via CRISPRchange donor?
KN208634G1, EXOSC6 gRNA vector 1 in pCas-Guide vector,
KN208634G2, EXOSC6 gRNA vector 2 in pCas-Guide vector,
donor vector containing Left and right homologous arms and GFP-puro functional cassette.
GE100003, scramble sequence in pCas-Guide vector
|Disclaimer||The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.|
|RefSeq||AK026155, NM_058219, XM_050885|
|Synonyms||EAP4; hMtr3p; MTR3; Mtr3p; p11|
|Summary||This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation. [provided by RefSeq, Jul 2008].|
|Gene Expression Resources|
"EXOSC6" in other Product Lines
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