MADD Human Gene Knockout Kit (CRISPR)

CAT#: KN206061

MADD - human gene knockout kit via CRISPR

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USD 1,290.00


Availability*
4 Weeks

Size
    • 1 kit

Product images

Specifications

Product Data
Symbol MADD
Locus ID 8567
Kit Components

KN206061G1, MADD gRNA vector 1 in pCas-Guide vector,

KN206061G2, MADD gRNA vector 2 in pCas-Guide vector,

KN206061-D, donor vector containing Left and right homologous arms and GFP-puro functional cassette.

GE100003, scramble sequence in pCas-Guide vector

Disclaimer The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001135943, NM_001135944, NM_003682, NM_130470, NM_130471, NM_130472, NM_130473, NM_130474, NM_130475, NM_130476, XM_005253189, XM_005253196, XM_005253199, XM_005253200, XM_005253201, XM_005253203, XM_005253204, XM_005253205, XM_017018478, XM_017018479, XM_017018480, XM_017018481, XM_017018482, XM_017018483, XM_017018484, XM_017018485, XM_017018486, XM_017018487, XM_017018488, XM_017018489, XM_017018490, XM_017018491, XM_017018492, XM_017018493, XM_017018494, XM_017018495, XM_017018496, XM_017018497, XM_017018498, XM_017018499, XM_017018500, XM_017018501, XM_017018502, XM_017018503, XM_017018504, XM_017018505, XM_017018506, XM_017018507, XM_017018508, XM_017018509, XM_017018510
Synonyms DENN; IG20; RAB3GEP
Summary Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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