MADD Human Gene Knockout Kit (CRISPR)
MADD - human gene knockout kit via CRISPRchange donor?
KN206061G1, MADD gRNA vector 1 in pCas-Guide vector,
KN206061G2, MADD gRNA vector 2 in pCas-Guide vector,
donor vector containing Left and right homologous arms and GFP-puro functional cassette.
GE100003, scramble sequence in pCas-Guide vector
|Disclaimer||The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.|
|RefSeq||NM_001135943, NM_001135944, NM_003682, NM_130470, NM_130471, NM_130472, NM_130473, NM_130474, NM_130475, NM_130476, XM_005253189, XM_005253196, XM_005253199, XM_005253200, XM_005253201, XM_005253203, XM_005253204, XM_005253205, XM_017018478, XM_017018479, XM_017018480, XM_017018481, XM_017018482, XM_017018483, XM_017018484, XM_017018485, XM_017018486, XM_017018487, XM_017018488, XM_017018489, XM_017018490, XM_017018491, XM_017018492, XM_017018493, XM_017018494, XM_017018495, XM_017018496, XM_017018497, XM_017018498, XM_017018499, XM_017018500, XM_017018501, XM_017018502, XM_017018503, XM_017018504, XM_017018505, XM_017018506, XM_017018507, XM_017018508, XM_017018509, XM_017018510|
|Synonyms||DENN; IG20; RAB3GEP|
|Summary||Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].|
|Gene Expression Resources|
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