PAOX (NM_207128) Human Tagged ORF Clone Lentiviral Particle

SKU RC224235L4V

Lenti ORF particles, PAOX (mGFP-tagged) - Human polyamine oxidase (exo-N4-amino) (PAOX), transcript variant 5, 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Target Symbol: PAOX
• Synonyms: PAO
• Vector: pLenti-C-mGFP-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC224235).
• ACCN: NM_207128
• ORF Size: 1458 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_207128.1
• RefSeq Size: 1720 bp
• RefSeq ORF: 1461 bp
• Locus ID: 196743
• UniProt ID: Q6QHF9
• Cytogenetics: 10q26.3
• Protein Families: Druggable Genome
• MW: 51.8 kDa
• Summary: Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion (PubMed:12477380). Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs (PubMed:12477380).[UniProtKB/Swiss-Prot Function]