ATP7B (NM_000053) Human Tagged ORF Clone Lentiviral Particle

SKU RC223635L4V

Lenti ORF particles, ATP7B (mGFP-tagged) - Human ATPase, Cu++ transporting, beta polypeptide (ATP7B), transcript variant 1, 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Target Symbol: ATP7B
• Synonyms: PWD; WC1; WD; WND
• Vector: pLenti-C-mGFP-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC223635).
• ACCN: NM_000053
• ORF Size: 4395 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_000053.2
• RefSeq Size: 6644 bp
• RefSeq ORF: 4398 bp
• Locus ID: 540
• UniProt ID: P35670
• Cytogenetics: 13q14.3
• Domains: E1-E2_ATPase, HMA, Hydrolase
• Protein Families: Druggable Genome, Transmembrane
• MW: 157.1 kDa
• Summary: This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein is a monomer, and functions as a copper-transporting ATPase which exports copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease which is characterized by copper accumulation. [provided by RefSeq, Dec 2019]