APXL (SHROOM2) (NM_001649) Human Tagged ORF Clone Lentiviral Particle

SKU RC222295L4V

Lenti ORF particles, SHROOM2 (mGFP-tagged)-Human shroom family member 2 (SHROOM2), 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Target Symbol: APXL
• Synonyms: APXL; HSAPXL
• Vector: pLenti-C-mGFP-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC222295).
• ACCN: NM_001649
• ORF Size: 4848 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_001649.2
• RefSeq Size: 7445 bp
• RefSeq ORF: 4851 bp
• Locus ID: 357
• UniProt ID: Q13796
• Cytogenetics: Xp22.2
• Protein Families: Druggable Genome
• MW: 176.2 kDa
• Summary: This gene represents the human homolog of Xenopus laevis apical protein (APX) gene, which is implicated in amiloride-sensitive sodium channel activity. It is expressed in endothelial cells and facilitates the formation of a contractile network within endothelial cells. Depletion of this gene results in an increase in endothelial sprouting, migration, and angiogenesis. This gene is highly expressed in the retina, and is a strong candidate for ocular albinism type 1 syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]