Nesprin3 (SYNE3) (NM_152592) Human Tagged ORF Clone Lentiviral Particle

SKU RC217809L4V

Lenti ORF particles, SYNE3 (mGFP-tagged) - Human chromosome 14 open reading frame 49 (C14orf49), 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Target Symbol: Nesprin3
• Synonyms: C14orf49; C14orf139; KASH3; LINC00341; NCRNA00341; Nesp3; NET53
• Vector: pLenti-C-mGFP-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC217809).
• ACCN: NM_152592
• ORF Size: 2925 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_152592.2, NP_689805.2
• RefSeq Size: 3175 bp
• RefSeq ORF: 2928 bp
• Locus ID: 161176
• UniProt ID: Q6ZMZ3
• Cytogenetics: 14q32.13
• Protein Families: Transmembrane
• MW: 112 kDa
• Summary: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells.[UniProtKB/Swiss-Prot Function]