SARM (SARM1) (NM_015077) Human Tagged ORF Clone Lentiviral Particle

SKU RC215903L2V

Lenti ORF particles, SARM1 (mGFP-tagged)-Human sterile alpha and TIR motif containing 1 (SARM1), 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Target Symbol: SARM
• Synonyms: hSARM1; HsTIR; MyD88-5; SAMD2; SARM
• Vector: pLenti-C-mGFP
• Mammalian Cell Selection: None
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC215903).
• ACCN: NM_015077
• ORF Size: 2172 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_015077.2
• RefSeq Size: 7001 bp
• RefSeq ORF: 2175 bp
• Locus ID: 23098
• UniProt ID: Q6SZW1
• Cytogenetics: 17q11.2
• Domains: SAM, TIR
• Protein Families: Druggable Genome
• MW: 79.2 kDa
• Summary: Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.[UniProtKB/Swiss-Prot Function]