PERK (EIF2AK3) (NM_004836) Human Tagged ORF Clone Lentiviral Particle

SKU RC214993L4V

Lenti ORF particles, EIF2AK3 (mGFP-tagged) - Human eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3), 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Target Symbol: PERK
• Synonyms: PEK; PERK; WRS
• Vector: pLenti-C-mGFP-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC214993).
• ACCN: NM_004836
• ORF Size: 3348 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_004836.3
• RefSeq Size: 4511 bp
• RefSeq ORF: 3351 bp
• Locus ID: 9451
• UniProt ID: Q9NZJ5
• Cytogenetics: 2p11.2
• Domains: pkinase, PQQ, S_TKc, TyrKc
• Protein Families: Druggable Genome, Protein Kinase, Secreted Protein, Transmembrane
• Protein Pathways: Alzheimer's disease
• MW: 125.26 kDa
• Summary: The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015]