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Hamartin (TSC1) (NM_000368) Human Tagged ORF Clone Lentiviral Particle

  • LentiORF®
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SKU
RC213332L2V
Lenti ORF particles, TSC1 (mGFP-tagged) - Human tuberous sclerosis 1 (TSC1), transcript variant 1, 200ul, >10^7 TU/mL
  $2,075.00
5 Weeks*
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Other products for "Hamartin or NM_000368"

Specifications
Specifications
Product Data
Type Human Tagged ORF Clone Lentiviral Particle
Tag mGFP
Target Symbol Hamartin
Synonyms LAM; TSC
Vector pLenti-C-mGFP
Mammalian Cell Selection None
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(RC213332).
ACCN NM_000368
ORF Size 3504 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Shipping Dry Ice
Reference Data
RefSeq NM_000368.3
RefSeq Size 8617 bp
RefSeq ORF 3495 bp
Locus ID 7248
UniProt ID Q92574
Cytogenetics 9q34.13
Domains Hamartin
Protein Pathways Insulin signaling pathway, mTOR signaling pathway
MW 130.3 kDa
Summary This gene is a tumor suppressor gene that encodes the growth inhibitory protein hamartin. The encoded protein interacts with and stabilizes the GTPase activating protein tuberin. This hamartin-tuberin complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signalling which is a major regulator of anabolic cell growth. This protein also functions as a co-chaperone for Hsp90 that inhibits its ATPase activity. This protein functions as a facilitator of Hsp90-mediated folding of kinase and non-kinase clients, including Tsc2 and thereby preventing their ubiquitination and proteasomal degradation. Mutations in this gene have been associated with tuberous sclerosis. provided by RefSeq, Apr 2018
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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