Jagged1 (JAG1) (NM_000214) Human Tagged ORF Clone Lentiviral Particle

SKU RC210516L2V

Lenti ORF particles, JAG1 (mGFP-tagged) - Human jagged 1 (JAG1), 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Target Symbol: Jagged1
• Synonyms: AGS; AGS1; AHD; AWS; CD339; DCHE; HJ1; JAGL1
• Vector: pLenti-C-mGFP
• Mammalian Cell Selection: None
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC210516).
• ACCN: NM_000214
• ORF Size: 3654 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_000214.1
• RefSeq Size: 5896 bp
• RefSeq ORF: 3657 bp
• Locus ID: 182
• UniProt ID: P78504
• Cytogenetics: 20p12.2
• Domains: DSL, EGF, EGF_CA, VWC, VWC_out
• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Notch signaling pathway
• MW: 133.6 kDa
• Summary: The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter is involved in signaling processes. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Nov 2019]