PON1 (NM_000446) Human Tagged ORF Clone Lentiviral Particle

SKU RC210356L2V

Lenti ORF particles, PON1 (mGFP-tagged) - Human paraoxonase 1 (PON1), 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Target Symbol: PON1
• Synonyms: ESA; MVCD5; PON
• Vector: pLenti-C-mGFP
• Mammalian Cell Selection: None
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC210356).
• ACCN: NM_000446
• ORF Size: 1065 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_000446.3
• RefSeq Size: 1769 bp
• RefSeq ORF: 1068 bp
• Locus ID: 5444
• UniProt ID: P27169
• Cytogenetics: 7q21.3
• Domains: Arylesterase
• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Metabolic pathways
• MW: 39.7 kDa
• Summary: This gene encodes a member of the paraoxonase family of enzymes and exhibits lactonase and ester hydrolase activity. Following synthesis in the kidney and liver, the enzyme is secreted into the circulation, where it binds to high density lipoprotein (HDL) particles and hydrolyzes thiolactones and xenobiotics, including paraoxon, a metabolite of the insecticide parathion. Polymorphisms in this gene may be associated with coronary artery disease and diabetic retinopathy. The gene is found in a cluster of three related paraoxonase genes on chromosome 7. [provided by RefSeq, Aug 2017]