SnoN (SKIL) (NM_005414) Human Tagged ORF Clone Lentiviral Particle

SKU RC209251L4V

Lenti ORF particles, SKIL (mGFP-tagged) - Human SKI-like oncogene (SKIL), transcript variant 1, 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Target Symbol: SnoN
• Synonyms: SNO; SnoA; SnoI; SnoN
• Vector: pLenti-C-mGFP-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC209251).
• ACCN: NM_005414
• ORF Size: 2052 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_005414.2, NP_005405.1
• RefSeq Size: 3111 bp
• RefSeq ORF: 2055 bp
• Locus ID: 6498
• UniProt ID: P12757
• Cytogenetics: 3q26.2
• Domains: Ski_Sno
• Protein Families: Druggable Genome, Transcription Factors
• MW: 76.8 kDa
• Summary: The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]