CD146 (MCAM) (NM_006500) Human Tagged ORF Clone Lentiviral Particle

SKU RC208937L2V

Lenti ORF particles, MCAM (mGFP-tagged) - Human melanoma cell adhesion molecule (MCAM), 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Target Symbol: CD146
• Synonyms: CD146; HEMCAM; MelCAM; METCAM; MUC18
• Vector: pLenti-C-mGFP
• Mammalian Cell Selection: None
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC208937).
• ACCN: NM_006500
• ORF Size: 1938 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_006500.2
• RefSeq Size: 3332 bp
• RefSeq ORF: 1941 bp
• Locus ID: 4162
• UniProt ID: P43121
• Cytogenetics: 11q23.3
• Domains: ig, IG, IGc2
• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• MW: 71.4 kDa
• Summary: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.[UniProtKB/Swiss-Prot Function]