Topoisomerase III alpha (TOP3A) (NM_004618) Human Tagged ORF Clone Lentiviral Particle

SKU RC208236L4V

Lenti ORF particles, TOP3A (mGFP-tagged)-Human topoisomerase (DNA) III alpha (TOP3A), 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Target Symbol: Topoisomerase III alpha
• Synonyms: MGRISCE2; PEOB5; TOP3; ZGRF7
• Vector: pLenti-C-mGFP-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC208236).
• ACCN: NM_004618
• ORF Size: 3003 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_004618.3
• RefSeq Size: 4116 bp
• RefSeq ORF: 3006 bp
• Locus ID: 7156
• UniProt ID: Q13472
• Cytogenetics: 17p11.2
• Domains: TOP1Ac, TOP1Bc, Topoisom_bac, Toprim, TOPRIM, zf-CCHC
• Protein Families: Druggable Genome
• Protein Pathways: Homologous recombination
• MW: 112.2 kDa
• Summary: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]