IKAP (IKBKAP) (NM_003640) Human Tagged ORF Clone Lentiviral Particle

SKU RC207686L4V

Lenti ORF particles, IKBKAP (mGFP-tagged) - Human inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein (IKBKAP), 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Target Symbol: IKAP
• Synonyms: DYS; FD; IKAP; IKBKAP; IKI3; TOT1
• Vector: pLenti-C-mGFP-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC207686).
• ACCN: NM_003640
• ORF Size: 3996 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_003640.2
• RefSeq Size: 5917 bp
• RefSeq ORF: 3999 bp
• Locus ID: 8518
• UniProt ID: O95163
• Cytogenetics: 9q31.3
• Domains: IKI3
• Protein Families: Druggable Genome
• MW: 150.1 kDa
• Summary: The protein encoded by this gene is a scaffold protein and a regulator for three different kinases involved in proinflammatory signaling. The encoded protein can bind NF-kappa-B-inducing kinase and I-kappa-B kinases through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]