GPNMB (NM_001005340) Human Tagged ORF Clone Lentiviral Particle

SKU RC207615L2V

Lenti ORF particles, GPNMB (mGFP-tagged) - Human glycoprotein (transmembrane) nmb (GPNMB), transcript variant 1, 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Target Symbol: GPNMB
• Synonyms: HGFIN; NMB; PLCA3
• Vector: pLenti-C-mGFP
• Mammalian Cell Selection: None
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC207615).
• ACCN: NM_001005340
• ORF Size: 1716 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_001005340.1, NP_001005340.1
• RefSeq Size: 2775 bp
• RefSeq ORF: 1719 bp
• Locus ID: 10457
• UniProt ID: Q14956
• Cytogenetics: 7p15.3
• Protein Families: Druggable Genome, Transmembrane
• MW: 63.92 kDa
• Summary: The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]