DNase I (DNASE1) (NM_005223) Human Tagged ORF Clone Lentiviral Particle

CAT#: RC205927L3V

Lenti ORF particles, DNASE1 (Myc-DDK tagged) - Human deoxyribonuclease I (DNASE1), 200ul, >10^7 TU/mL

Specifications

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: Myc-DDK
• Symbol: DNase I
• Synonyms: DNL1; DRNI
• Mammalian Cell Selection: Puromycin
• Vector: pLenti-C-Myc-DDK-P2A-Puro
• ACCN: NM_005223
• ORF Size: 846 bp
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC205927).
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.

Reference Data

• RefSeq: NM_005223.3, NP_005214.2
• RefSeq Size: 3108 bp
• RefSeq ORF: 849 bp
• Locus ID: 1773
• UniProt ID: P24855
• Cytogenetics: 16p13.3
• Domains: Exo_endo_phos, DNaseIc
• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• MW: 31.4 kDa
• Gene Summary: This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]