EDEM1 (NM_014674) Human Tagged ORF Clone Lentiviral Particle

SKU RC205655L4V

Lenti ORF particles, EDEM1 (mGFP-tagged) - Human ER degradation enhancer, mannosidase alpha-like 1 (EDEM1), 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Target Symbol: EDEM1
• Synonyms: EDEM
• Vector: pLenti-C-mGFP-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC205655).
• ACCN: NM_014674
• ORF Size: 1971 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_014674.1, NP_055489.1
• RefSeq Size: 6072 bp
• RefSeq ORF: 1974 bp
• Locus ID: 9695
• UniProt ID: Q92611
• Cytogenetics: 3p26.1
• Domains: Glyco_hydro_47
• Protein Families: Transmembrane
• MW: 73.6 kDa
• Summary: Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2.[UniProtKB/Swiss-Prot Function]