NEURL (NEURL1) (NM_004210) Human Tagged ORF Clone Lentiviral Particle

SKU RC205357L4V

Lenti ORF particles, NEURL (mGFP-tagged)-Human neuralized homolog (Drosophila) (NEURL), 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Target Symbol: NEURL
• Synonyms: bA416N2.1; neu; neu-1; NEUR1; NEURL; RNF67
• Vector: pLenti-C-mGFP-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC205357).
• ACCN: NM_004210
• ORF Size: 1722 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_004210.4
• RefSeq Size: 4315 bp
• RefSeq ORF: 1725 bp
• Locus ID: 9148
• UniProt ID: O76050
• Cytogenetics: 10q24.33
• Domains: NEUZ
• Protein Families: Druggable Genome
• MW: 61.9 kDa
• Summary: Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.[UniProtKB/Swiss-Prot Function]