LINGO1 (NM_032808) Human Tagged ORF Clone Lentiviral Particle

SKU RC203867L2V

Lenti ORF particles, LINGO1 (mGFP-tagged) - Human leucine rich repeat and Ig domain containing 1 (LINGO1), 200ul, >10^7 TU/mL

Product Data

• Type: Human Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Target Symbol: LINGO1
• Synonyms: LERN1; LRRN6A; MRT64; UNQ201
• Vector: pLenti-C-mGFP
• Mammalian Cell Selection: None
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(RC203867).
• ACCN: NM_032808
• ORF Size: 1860 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_032808.5
• RefSeq Size: 3109 bp
• RefSeq ORF: 1863 bp
• Locus ID: 84894
• UniProt ID: Q96FE5
• Cytogenetics: 15q24.3
• Domains: ig, IG, IGc2, LRR, LRRCT
• Protein Families: Druggable Genome, Transmembrane
• MW: 69.9 kDa
• Summary: Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors (PubMed:14966521, PubMed:15694321). Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed:15895088). Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity).[UniProtKB/Swiss-Prot Function]