Topors (NM_134097) Mouse Tagged ORF Clone Lentiviral Particle

SKU MR222286L4V

Lenti ORF particles, Topors (GFP-tagged) - Mouse topoisomerase I binding, arginine/serine-rich (Topors), 200ul, >10^7 TU/mL

Product Data

• Type: Mouse Tagged ORF Clone Lentiviral Particle
• Tag: mGFP
• Target Symbol: Topors
• Synonyms: AW105885; LUN; p53BP3/LUN; TP53BPL
• Vector: pLenti-C-mGFP-P2A-Puro
• Mammalian Cell Selection: Puromycin
• Sequence Data:
  ORF Nucleotide Sequence

  The ORF insert of this clone is exactly the same as(MR222286).
• ACCN: NM_134097
• ORF Size: 3099 bp
• OTI Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Shipping: Dry Ice

Reference Data

• RefSeq: NM_134097.3, NP_598858.2
• RefSeq Size: 3842 bp
• RefSeq ORF: 3102 bp
• Locus ID: 106021
• UniProt ID: Q80Z37
• Cytogenetics: 4 A5
• Summary: Functions as an E3 ubiquitin-protein ligase and as a E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA-damage-induced cell death through IKBKE sumoylation.[UniProtKB/Swiss-Prot Function]