p63 (TP63) (NM_003722) Human Untagged Clone

CAT#: SC322630

TP63 (untagged)-Human tumor protein p63 (TP63), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: p63
• Synonyms: AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP; OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4; TP53CP; TP53L; TP73L
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for SC322630 CCCGGCTTTATATCTATATATACACAGGTATATGTGTATATTTTATATAATTGTTCTCCG
  TTCGTTGATATCAAAGACAGTTGAAGGAAATGAATTTTGAAACTTCACGGTGTGCCACCC
  TACAGTACTGCCCTGACCCTTACATCCAGCGTTTCGTAGAAACCCCAGCTCATTTCTCTT
  GGAAAGAAAGTTATTACCGATCCACCATGTCCCAGAGCACACAGACAAATGAATTCCTCA
  GTCCAGAGGTTTTCCAGCATATCTGGGATTTTCTGGAACAGCCTATATGTTCAGTTCAGC
  CCATTGACTTGAACTTTGTGGATGAACCATCAGAAGATGGTGCGACAAACAAGATTGAGA
  TTAGCATGGACTGTATCCGCATGCAGGACTCGGACCTGAGTGACCCCATGTGGCCACAGT
  ACACGAACCTGGGGCTCCTGAACAGCATGGACCAGCAGATTCAGAACGGCTCCTCGTCCA
  CCAGTCCCTATAACACAGACCACGCGCAGAACAGCGTCACGGCGCCCTCGCCCTACGCAC
  AGCCCAGCTCCACCTTCGATGCTCTCTCTCCATCACCCGCCATCCCCTCCAACACCGACT
  ACCCAGGCCCGCACAGTTTCGACGTGTCCTTCCAGCAGTCGAGCACCGCCAAGTCGGCCA
  CCTGGACGTATTCCACTGAACTGAAGAAACTCTACTGCCAAATTGCAAAGACATGCCCCA
  TCCAGATCAAGGTGATGACCCCACCTCCTCAGGGAGCTGTTATCCGCGCCATGCCTGTCT
  ACAAAAAAGCTGAGCACGTCACGGAGGTGGTGAAGCGGTGCCCCAACCATGAGCTGAGCC
  GTGAATTCAACGAGGGACAGATTGCCCCTCCTAGTCATTTGATTCGAGTAGAGGGGAACA
  GCCATGCCCAGTATGTAGAAGATCCCATCACAGGAAGACAGAGTGTGCTGGTACCTTATG
  AGCCACCCCAGGTTGGCACTGAATTCACGACAGTCTTGTACAATTTCATGTGTAACAGCA
  GTTGTGTTGGAGGGATGAACCGCCGTCCAATTTTAATCATTGTTACTCTGGAAACCAGAG
  ATGGGCAAGTCCTGGGCCGACGCTGCTTTGAGGCCCGGATCTGTGCTTGCCCAGGAAGAG
  ACAGGAAGGCGGATGAAGATAGCATCAGAAAGCAGCAAGTTTCGGACAGTACAAAGAACG
  GTGATGGTACGAAGCGCCCGTTTCGTCAGAACACACATGGTATCCAGATGACATCCATCA
  AGAAACGAAGATCCCCAGATGATGAACTGTTATACTTACCAGTGAGGGGCCGTGAGACTT
  ATGAAATGCTGTTGAAGATCAAAGAGTCCCTGGAACTCATGCAGTACCTTCCTCAGCACA
  CAATTGAAACGTACAGGCAACAGCAACAGCAGCAGCACCAGCACTTACTTCAGAAACAGA
  CCTCAATACAGTCTCCATCTTCATATGGTAACAGCTCCCCACCTCTGAACAAAATGAACA
  GCATGAACAAGCTGCCTTCTGTGAGCCAGCTTATCAACCCTCAGCAGCGCAACGCCCTCA
  CTCCTACAACCATTCCTGATGGCATGGGAGCCAACATTCCCATGATGGGCACCCACATGC
  CAATGGCTGGAGACATGAATGGACTCAGCCCCACCCAGGCACTCCCTCCCCCACTCTCCA
  TGCCATCCACCTCCCACTGCACACCCCCACCTCCGTATCCCACAGATTGCAGCATTGTCA
  GTTTCTTAGCGAGGTTGGGCTGTTCATCATGTCTGGACTATTTCACGACCCAGGGGCTGA
  CCACCATCTATCAGATTGAGCATTACTCCATGGATGATCTGGCAAGTCTGAAAATCCCTG
  AGCAATTTCGACATGCGATCTGGAAGGGCATCCTGGACCACCGGCAGCTCCACGAATTCT
  CCTCCCCTTCTCATCTCCTGCGGACCCCAAGCAGTGCCTCTACAGTCAGTGTGGGCTCCA
  GTGAGACCCGGGGTGAGCGTGTTATTGATGCTGTGCGATTCACCCTCCGCCAGACCATCT
  CTTTCCCACCCCGAGATGAGTGGAATGACTTCAACTTTGACATGGATGCTCGCCGCAATA
  AGCAACAGCGCATCAAAGAGGAGGGGGAGTGAGCCTCACCATGTGAGCTCTTCCTATCCC
  TCTCCTAACTGCCAGCCCCCTAAAAGCACTCCTGCTTAATCTTCAAAGCCTTCTCCCTAG
  CTCCTCCCCTTCCTCTTGTCTGATTTCTTAGGGGAAGGAGAAGTAAGAGGCTACCTCTTA
  CCTAACATCTGACCTGGCATCTAATTCTGATTCTGGCTTTAAGCCTTCAAAACTATAGCT
  TGCAGAACTGTAGCTGCCATGGCTAGGTAGAAGTGAGCAAAAAAGAGTTGGGTGTCTCCT
  TAAGCTGCAGAGATTTCTCATTGACTTTTATAAAGCATGTTCACCCTTATAGTCTAAGAC
  TATATATATAAATGTATAAATATACAGTATAGATTTTTGGGTGGGGGGCATTGAGTATTG
  TTTAAAATGTAATTTAAATGAAAGAAAATTGAGTTGCACTTATTGACCATTTTTTAATTT
  ACTTGTTTTGGATGGCTTGTCTATACTCCTTCCCTTAAGGGGTATCATGTATGGTGATAG
  GTATCTAGAGCTTAATGCTACATGTGAGTGACGATGATGTACAGATTCTTTCAGTTCTTT
  GGATTCTAAATACATGCCACATCAAACCTTTGAGTAGATCCATTTCCATTGCTTATTATG
  TAGGTAAGACTGTAGATATGTATTCTTTTCTCAGTGTTGGTATATTTTATATTACTGACA
  TTTCTTCTAGTGATGATGGTTCACGTTGGGGTGATTTAATCCAGTTATAAGAAGAAGTTC
  ATGTCCAAACGTCCTCTTTAGTTTTTGGTTGGGAATGAGGAAAATTCTTAAAAGGCCCAT
  AGCAGCCAGTTCAAAAACACCCGACGTCATGTATTTGAGCATATCAGTAACCCCCTTAAA
  TTTAATACCAGATACCTTATCTTACAATATTGATTGGGAAAACATTTGCTGCCATTACAG
  AGGTATTAAAACTAAATTTCACTACTAGATTGACTAACTCAAATACACATTTGCTACTGT
  TGTAAGAATTCTGATTGATTTGATTGGGATGAATGCCATCTATCTAGTTCTAACAGTGAA
  GTTTTACTGTCTATTAATATTCAGGGTAAATAGGAATCATTCAGAAATGTTGAGTCTGTA
  CTAAACAGTAAGATATCTCAATGAACCATAAATTCAACTTTGTAAAAATCTTTTGAAGCA
  TAGATAATATTGTTTGGTAAATGTTTCTTTTGTTTGGTAAATGTTTCTTTTAAAGACCCT
  CCTATTCTATAAAACTCTGCATGTAGAGGCTTGTTTACCTTTCTCTCTCTAAGGTTTACA
  ATAGGAGTGGTGATTTGAAAAATATAAAATTATGAGATTGGTTTTCCTGTGGCATAAATT
  GCATCACTGTATCATTTTCTTTTTTAACCGGTAAGAGTTTCAGTTTGTTGGAAAGTAACT
  GTGAGAACCCAGTTTCCCGTCCATCTCCCTTAGGGACTACCCATAGACATGAAAGGTCCC
  CACAGAGCAAGAGATAAGTCTTTCATGGCTGCTGTTGCTTAAACCACTTAAACGAAGAGT
  TCCCTTGAAACTTTGGGAAAACATGTTAATGACAATATTCCAGATCTTTCAGAAATATAA
  CACATTTTTTTGCATGCATGCAAATGAGCTCTGAAATCTTCCCATGCATTCTGGTCAAGG
  GCTGTCATTGCACATAAGCTTCCATTTTAATTTTAAAGTGCAAAAGGGCCAGCGTGGCTC
  TAAAAGGTAATGTGTGGATTGCCTCTGAAAAGTGTGTATATATTTTGTGTGAAATTGCAT
  ACTTTGTATTTTGATTATTTTTTTTTTCTTCTTGGGATAGTGGGATTTCCAGAACCACAC
  TTGAAACCTTTTTTTATCGTTTTTGTATTTTCATGAAAATACCATTTAGTAAGAATACCA
  CATCAAATAAGAAATAATGCTACAATTTTAAGAGGGGAGGGAAGGGAAAGTTTTTTTTTA
  TTATTTTTTTAAAATTTTGTATGTTAAAGAGAATGAGTCCTTGATTTCAAAGTTTTGTTG
  TACTTAAATGGTAATAAGCACTGTAAACTTCTGCAACAAGCATGCAGCTTTGCAAACCCA
  TTAAGGGGAAGAATGAAAGCTGTTCCTTGGTCCTAGTAAGAAGACAAACTGCTTCCCTTA
  CTTTGCTGAGGGTTTGAATAAACCTAGGACTTCCGAGCTATGTCAGTACTATTCAGGTAA
  CACTAGGGCCTTGGAAATTCCTGTACTGTGTCTCATGGATTTGGCACTAGCCAAAGCGAG
  GCACCCTTACTGGCTTACCTCCTCATGGCAGCCTACTCTCCTTGAGTGTATGAGTAGCCA
  GGGTAAGGGGTAAAAGGATAGTAAGCATAGAAACCATTAGAAAGTGGGCTTAATGGAGTT
  CTTGTGGCCTCAGCTCAATGCAGTTAGCTGAAGAATTGAAAAGTTTTTGTTTGGAGACGT
  TTATAAACAGAAATGGAAAGCAGAGTTTTCATTAAATCCTTTTACCTTTTTTTTTTCTTG
  GTAATCCCCTAAAATAACAGTATGTGGGATATTGAATGTTAAAGGGATATTTTTTTCTAT
  TATTTTTATAATTGTACAAAATTAAGCAAATGTTAAAAGTTTTATATGCTTTATTAATGT
  TTTCAAAAGGTATTATACATGTGATACATTTTTTAAGCTTCAGTTGCTTGTCTTCTGGTA
  CTTTCTGTTATGGGCTTTTGGGGAGCCAGAAGCCAATCTACAATCTCTTTTTGTTTGCCA
  GGACATGCAATAAAATTTAAAAAATAAATAAAAACTAATTAAGAAAAAAAAAAAAAAAAA
  AAAAAAAAAAAA
• Restriction Sites: Please inquire
• ACCN: NM_003722
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_003722.3, NP_003713.3
• RefSeq Size: 4932 bp
• RefSeq ORF: 2043 bp
• Locus ID: 8626
• UniProt ID: Q9H3D4
• Cytogenetics: 3q28
• Domains: SAM, P53
• Protein Families: Druggable Genome, Transcription Factors
• Gene Summary: This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. [provided by RefSeq, Aug 2016]
  Transcript Variant: This variant (1) is the longest transcript and encodes the longest isoform (1, also known as TAp63alpha, TA-alpha, KET, and p51B). This isoform is expressed in female germ cells and acts to protect the germline by eliminating oocytes that have suffered DNA damage.